Readiness before the trial
Liberation begins with the disease, not the ventilator. The cause of the failure must be improving.
- Reversal of the underlying cause, hemodynamic stability on minimal vasopressors, and adequate mental status.
- Oxygenation: PaO2/FiO2 >150–200 on FiO2 ≤0.40–0.50 and PEEP ≤5–8 cm H2O.
- Ability to initiate an inspiratory effort and to protect the airway with an effective cough.
- Secretions manageable — suctioning needed less often than roughly every 2 hours.
Extubation failure is usually an airway problem, not a lung problem. Judge the cough before the gas.